Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-10-10
2006-10-10
Wilson, James O. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C544S408000
Reexamination Certificate
active
07119094
ABSTRACT:
The invention relates to substituted polycyclic aryl and heteroaryl pyrazinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.
REFERENCES:
patent: 4489096 (1984-12-01), Terao et al.
patent: 4802908 (1989-02-01), Hillemann
patent: 4851413 (1989-07-01), Terao et al.
patent: 4871853 (1989-10-01), Bohner et al.
patent: 4992469 (1991-02-01), Ozawa et al.
patent: 5304658 (1994-04-01), Terao et al.
patent: 5441960 (1995-08-01), Bernstein et al.
patent: 5656645 (1997-08-01), Tamura et al.
patent: 5658930 (1997-08-01), Tamura et al.
patent: 5668289 (1997-09-01), Sanderson et al.
patent: 5741819 (1998-04-01), Illig et al.
patent: 5792779 (1998-08-01), Sanderson et al.
patent: 5861380 (1999-01-01), Gyorkos et al.
patent: 5866573 (1999-02-01), Sanderson et al.
patent: 5869487 (1999-02-01), Coburn et al.
patent: 5872138 (1999-02-01), Naylor-Olsen et al.
patent: 6011158 (2000-01-01), Tamura et al.
patent: 6037356 (2000-03-01), Lu et al.
patent: 6093717 (2000-07-01), Sanderson et al.
patent: 6180627 (2001-01-01), Blagg et al.
patent: 6387911 (2002-05-01), Burgey et al.
patent: 6506754 (2003-01-01), Siev et al.
patent: 6506760 (2003-01-01), Araldi et al.
patent: 198 51 421 (2000-05-01), None
patent: 0 354 495 (1990-02-01), None
patent: 0 528 633 (1993-02-01), None
patent: 0 826 671 (1998-03-01), None
patent: 0 936 216 (1999-08-01), None
patent: 0 940 400 (1999-09-01), None
patent: 0 997 474 (2000-05-01), None
patent: WO 93/21214 (1993-10-01), None
patent: WO 96/18644 (1996-06-01), None
patent: WO 96/33974 (1996-10-01), None
patent: WO 96/39380 (1996-12-01), None
patent: WO 96/40100 (1996-12-01), None
patent: WO 97/01338 (1997-01-01), None
patent: WO 97/30708 (1997-08-01), None
patent: WO 97/40024 (1997-10-01), None
patent: WO 97/46207 (1997-12-01), None
patent: WO 98/08840 (1998-03-01), None
patent: WO 98/09949 (1998-03-01), None
patent: WO 98/09987 (1998-03-01), None
patent: WO 98/10763 (1998-03-01), None
patent: WO 98/16525 (1998-04-01), None
patent: WO 98/16547 (1998-04-01), None
patent: WO 98/17274 (1998-04-01), None
patent: WO 98/31670 (1998-07-01), None
patent: WO 98/42342 (1998-10-01), None
patent: WO 98/47876 (1998-10-01), None
patent: WO 98/50420 (1998-11-01), None
patent: WO 99/00121 (1999-01-01), None
patent: WO 99/00126 (1999-01-01), None
patent: WO 99/00128 (1999-01-01), None
patent: WO 99/11267 (1999-03-01), None
patent: WO 99/26920 (1999-06-01), None
patent: WO 99/26926 (1999-06-01), None
patent: WO 99/36426 (1999-07-01), None
patent: WO 99/43660 (1999-09-01), None
patent: WO 99/48892 (1999-09-01), None
patent: WO 99/59591 (1999-11-01), None
patent: WO 99/61442 (1999-12-01), None
patent: WO 99/62538 (1999-12-01), None
patent: WO 99/64446 (1999-12-01), None
patent: WO 00/18762 (2000-04-01), None
patent: WO 00/26210 (2000-05-01), None
patent: WO 00/26211 (2000-05-01), None
patent: WO 00/32574 (2000-06-01), None
patent: WO 00/39102 (2000-07-01), None
patent: WO 00/69826 (2000-11-01), None
patent: WO 00/69832 (2000-11-01), None
patent: WO 00/69833 (2000-11-01), None
patent: WO 01/77097 (2001-10-01), None
Coburn, C.A., “Small-moleclule direct thrombine inhibitors 1997-2000.” Expert Opinions on Therapeutic Patents, 2001, 721-738, vol. 11, No. 5.
XP-002182132—Darvas, et al., “Investigation of the Common Mechanism of Action of Antibacterial Compounds Containing .gamma.-pyridone-.beta.-carboxylic acid Structure by Principal Component.” Arzneim.-Fosch., 1979, pp. 1334-1339, vol. 29, 9.
Handin, R., “Bleeding and Thrombosis.” Harrison's Principles of Internal Medicine, 12th Edition, 1991, pp. 348-353, McGraw-Hill, Inc., New York.
XP-002172033—Kohama et al., “Preparation of Piperidinyloxyacetylaminobenzoylalanine Derivatives and Analogs as Antithrombotics.” JP 07,233,148.
Majerus, et al. “Anticoagulant, Thrombolytic, and Antiplatlet Drugs.” Goodman & Gilman's The Pharmacological Basis of Therapeutics, Ninth Edition, 1996, pp. 1341-1359, McGraw-Hill, New York.
XP-002187583—Moerner, Hoppe-Seyler's Z. Physiol. Chem., 69, 1910; 357.
Patel et al., “Directed Aminomethylation of 3-Hydroxy-3(1H)-pyridinones and 3-hydroxy-4(1H)-pyridinones: Synthesis of iso-Deferiprone.” Tetrahedron, 1996, pp. 1835-1840, vol. 52, No. 5.
Rauch et al., “Thrombus Formation on Atheroscleratic Plaques: Pathogenesis and Clinical Consequences.” Animals of Internal Medicine, 2001, pp. 224-233, vol. 134, No. 3.
Sanderson et al., “L-373,890, An Achiral, Noncovalent, Subnamomolar Thrombin Inhibitor.” Bioorganic & Medicinal Chemistry Letters, vol. 7, No. 12, pp. 1497-1500, 1997.
XP-002182410—Trecourt et al., “First Synthesis of (+−)-harzianopyridone by Metalation of Polysubstituted O-pyridylcarbamates.” J. Heterocycl. Chem., 1995, pp. 1117-1114, vol. 32, No. 4.
Tulinsky et al., “Novel Asymmetric Synthesis of Atropisomeric 6-Aryl Pyrazinones via an Unusual Chirality Transfer Process.” J. Org. Chem., 1999, pp. 93-100, vol. 64, No. 1.
Van Aken, et al., “Anticoagulation: The Present and Future.” Clin. Appl. Thromiosis/Hemostasis, 2001, vol. 7, No. 3.
Barlin, B.G., “Purine Analogues as Amplifiers of Phleomcin. VII*, Some 1-Imidazo[4,5-b]pyrazines and Related Compounds”, Australian Journal of Chemistry, (1982), pp. 2299-2306, vol. 35:11.
Cheeseman, G.W.H. et al., “Pyrazines. Part II.1The Preparation and Reactions of 2,3-, 2,5-, and 2,6-Disubstituted Pyrazines”, Journal of The Chemical Society, (1965), pp. 6681-6688.
Case Brenda
Dice Tom
Fenton Rick
Franklin Gary W.
Hayes Michael J.
Ashbrook Charles W.
Eck Steven R.
Tucker Zachary C.
Warner-Lambert & Company
Wilson James O.
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