Substituted piperidinomethylindolone and cyclopent(b)indolone de

Details Substituted piperidinomethylindolone and cyclopent(b)indolone de Substituted piperidinomethylindolone and cyclopent(b)indolone de

1986-11-25

1987-11-17

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 20, A61K 31395, C07D52100

Patent

active

047074841

ABSTRACT:
Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, lower alkyl or acyl; R.sub.2 and R.sub.3 independently are lower alkyl, aralkyl or alkenyl or R.sub.2 and R.sub.3 together form a ring of 5 to 8 carbon atoms; R.sub.4 is phenyl, substituted phenyl, cyclohexyl, substituted cyclohexyl, cyclopentyl, substituted cyclopentyl, cycloheptyl, or substituted cycloheptyl; R.sub.5 is hydrogen or lower alkyl; R.sub.6 is hydrogen, lower alkyl or acyl; and pharmaceutically acceptable acid addition salts thereof are described. The compounds of formula I and pharmaceutically acceptable acid addition salts thereof are anti-emetic agents which lack central nervous system side effects.

REFERENCES:
patent: 3467755 (1969-09-01), Schoen et al.
patent: 3759927 (1973-09-01), Huebner

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