Substituted piperidines therapeutic process and compositions

Details Substituted piperidines therapeutic process and compositions Substituted piperidines therapeutic process and compositions

1979-11-28

1981-12-01

Friedman, Stanley J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424267, A61K 2700, C07D21100

Patent

active

RE0308129

ABSTRACT:
The compounds are of the heterocyclic class of 2-phenethylpiperidines having an amido substituent in the ortho position of the phenethyl moiety. Substituents in the ortho position include formamido, benzamido, cinnamamido, 2-thiophenecarboxamido, alkanesulfonamido and alkanoylamido. They are useful as antiarrhythmic and/or antiserotonin agents. The novel compounds are prepared by reaction of appropriately substituted o-aminophenethylpiperidines and the carbonyl or sulfonyl halides or anhydrides. Typical embodiments of this invention are 4-methoxy-2'-[2-(1-methyl-2-piperidyl)ethyl]benzanilide and 2'-[2-(1-methyl-2-piperidyl)ethyl]cinnamanilide.

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Krapcho et al., J. Med. Chem., 12, pp. 164-166 (1969).
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