Substituted piperidine derivative and medicine comprising the sa

Details Substituted piperidine derivative and medicine comprising the sa Substituted piperidine derivative and medicine comprising the sa

1996-06-26

1999-10-19

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546224, 546213, 546194, 514318, 514326, A61K 31445, C07D21156

Patent

active

059689560

ABSTRACT:
Disclosed herein is a substituted piperidine derivative represented by the following general formula (1): ##STR1## wherein R.sup.1 means an aryl or heteroaryl group which may have at least one substituent, R.sup.2 denotes an alkyl, alkenyl or aralkyl group, R.sup.3 stands for a hydrogen atom or an alkyl group, and R.sup.4 is a hydrogen atom, an alkyl group, or an aryl, heteroaryl, aralkyl, aralkenyl or heteroaralkyl group which may have at least one substituent, or a salt thereof. A medicine including this compound is also disclosed. The compound has excellent anticholinergic effect and calcium antagonism and inhibits reflex bladder contraction and is hence useful for prophylaxis of and treatment for a urinary disturbance such as pollakiuria.

REFERENCES:
patent: 5750540 (1998-05-01), Tsuchiya et al.
Patent Abstracts of Japan, vol. 18, No. 443 (C-1239), Aug. 18, 1994, JP-A-06-135958, May 17, 1994.

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