Substituted-phthalazone 7-carboxylic acid and salts and process

Details Substituted-phthalazone 7-carboxylic acid and salts and process Substituted-phthalazone 7-carboxylic acid and salts and process

1977-03-18

1980-01-08

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

424250, C07D23732, A61K 3150

Patent

active

041828763

ABSTRACT:
Phthalazone derivatives of the formula ##STR1## wherein R.sup.4 represents a carbamoyl group, a dialkylaminoalkylcarbamoyl group, a hydroxyalkylcarbamoyl group, an alkylidenehydrazinocarbonyl group, a hydrazinocarbonyl group, an alkylhydrazinocarbonyl group, a formyl group, a hydrazonomethyl group, an alkylhydrazonomethyl group, a hydroxyiminomethyl group, a dialkylhydrazonomethyl group or an alkylidenehydrazonomethyl group; R.sup.6, R.sup.7 and R.sup.8 each represent an alkyl group; and process for preparing same. The phthalazone derivatives are useful for the treatment and prevention of cerebral apoplexy, myocardial infarction and the like.

REFERENCES:
patent: 3864343 (1975-02-01), Inoue et al.
patent: 3963716 (1976-06-01), Inoue et al.
Sandler et al., "Organic Function Group Preparations".

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