Substituted phosphinic acid-containing peptidyl derivatives as a

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514417, 514422, 514429, 514399, 514418, 514419, 548413, 548414, 548415, 548481, 548472, 548491, 548112, 549 58, 549 5, 549220, 549 48, 549221, 546145, 546117, 544243, 544337, 568 15, 558170, A61K 3140, C07F 930

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056797001

ABSTRACT:
Novel phosphinic acid-containing peptidyl compounds of formula I are found to be useful inhibitors of matrix metalloendoproteinase-mediated diseases including osteoarthritis, rheumatoid arthritis, septic arthritis, tumor invasion in certain cancers, periodontal disease, corneal ulceration, proteinuria, dystrophobic epidermolysis bullosa, and coronary thrombosis associated with atherosclerotic plaque rupture. These inhibitors may also be useful in preventing the pathological sequelae following a traumatic injury that could lead to permanent disability. These compounds may also have utility as a means for birth control by preventing ovulation or implantation. ##STR1##

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