Substituted phenylpropionic acid derivatives

Details Substituted phenylpropionic acid derivatives Substituted phenylpropionic acid derivatives

2006-05-23

2006-05-23

Tsang, Cecilia J. (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

C514S562000, C562S450000, C562S405000, C562S442000, C562S443000

Reexamination Certificate

active

07049342

ABSTRACT:
The invention provides novel substituted phenylpropionic acid derivatives that bind to the receptor as ligands of human peroxisome proliferator-activated receptor α (PPARα) to activate and exhibit potent lipid-decreasing action, and processes for preparing them.It relates to substituted phenylpropionic acid derivatives represented by a general formula (1)[wherein R1denotes a lower alkyl group with carbon atoms of 1 to 4, lower alkoxy group with carbon atoms of 1 to 3, trifluoromethyl group, trifluoromethoxy group, phenyl group which is unsubstituted or may have substituents, phenoxy group which is unsubstituted or may have substituents or benzyloxy group which is unsubstituted or may have substituents, R2denotes a hydrogen atom, lower alkyl group with carbon atoms of 1 to 4 or lower alkoxy group with carbon atoms of 1 to 3, R3denotes a lower alkoxy group with carbon atoms of 1 to 3, and the binding mode of A portion denotes —CH2CONH—, —NHCOCH2—, —CH2CH2CO—, —CH2CH2CH2—, —CH2CH2O—, —CONHCH2—, —CH2NHCH2—, —COCH2O—, —OCH2CO—, —COCH2NH— or —CHCH2CO—], their pharmaceutically acceptable salts and their hydrates, and processes for preparing them.

REFERENCES:
patent: 6506797 (2003-01-01), Nomura et al.
patent: 0 930 299 (1997-08-01), None
patent: 97/36862 (1997-10-01), None
patent: 00/75103 (2000-12-01), None
patent: 01/25181 (2001-04-01), None
Juan Zhang et al.: “Polyphosphoric acid catalyzed conversion of 3-(methoxyphenyl)propionic acids to derivatives of [3.3]metacyclophane-1,10-diones and 1-indanones” J. Org. Chem., vol. 58, No. 3. pp. 556-559 1993.

Affiliated with

Also associated with

Rating

Substituted phenylpropionic acid derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Substituted phenylpropionic acid derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted phenylpropionic acid derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3636867