Substituted phenylisothioureas and processes for their preparati

Details Substituted phenylisothioureas and processes for their preparati Substituted phenylisothioureas and processes for their preparati

1976-06-04

1977-05-03

Mars, Howard T.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

260465X, 260465F, 260468E, 260470, 260471A, 260558R, 260558S, 260559R, 260566R, 424303, 424304, 424309, 424320, 424322, 424327, 424335, A01N 912

Patent

active

040215717

ABSTRACT:
N-[2-(Substituted amido)phenyl]-N'-carbonyl-S-substituted isothioureas bearing an optionally substituted phenoxy, phenylthio, phenylsulfinyl or phenylsulfonyl group in the 4- or 5-position of the 2-(substituted amido)-phenyl group are anthelmintic agents. The compounds, of which N-(2-acetamido-4-phenoxyphenyl)-N'-carbomethoxy-S-methylthiourea is a typical example, are prepared through the reaction of S-substituted N-(mercaptohalomethylene)carbamic acid ester and an appropriately substituted 2-aminoanilide, or through alkylation of the corresponding S-unsubstituted thiourea.

REFERENCES:
patent: 3649679 (1972-03-01), Marshall
patent: 3766243 (1973-10-01), Widdig et al.
patent: 3843215 (1974-10-01), Widdig et al.

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