Substituted phenylglycolic acid and its pharmaceutically accepta

Details Substituted phenylglycolic acid and its pharmaceutically accepta Substituted phenylglycolic acid and its pharmaceutically accepta

1977-11-15

1979-08-28

Reamer, James H.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

560 45, 562454, 424309, A01N 920, C07C10172

Patent

active

041661281

ABSTRACT:
Novel substituted phenylglycolic acid represented by the formula ##STR1## AND ITS PHARMACEUTICALLY ACCEPTABLE NON-TOXIC ESTERS AND SALTS HAVE POTENT ANALGESIC, ANTI-INFLAMMATORY AND ANTIPYRETIC ACTIVITIES, A LOW TOXICITY AND A SATISFACTORY THERAPEUTIC INDEX, AND CAN BE FAVORABLY EMPLOYED AS A MEDICINE FOR TREATMENT OF VARIOUS INFLAMMATORY DISEASES SUCH AS ARTHRITIS, COMMON COLD, RHEUMATISM AND LIKE INFLAMMATIONS AND ALSO FOR ANALGESIC AND ANTIPYRETIC PURPOSES. The substituted phenylglycolic acid is prepared by reacting a lower alkyl ester of 2-(2,6-dichloroanilino)phenylglycolic acid with a basic substance, which lower alkyl ester is also a novel compound and can be obtained starting from 1-(2,6-dichlorophenyl)indole-2,3-dione through 2-(2,6-dichloroanilino)phenylglyoxylic acid and, in turn, a lower alkyl ester of 2-(2,6-dichloroanilino)-phenylglyoxylic acid.

REFERENCES:
patent: 3558690 (1971-01-01), Sallmann et al.
patent: 3652762 (1972-03-01), Sallmann et al.
patent: 3681394 (1972-08-01), Sherlock
patent: 3766260 (1973-10-01), Carney et al.
patent: 3778470 (1973-12-01), Sallmann et al.

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