Substituted phenylacetic acid derivatives and process for the pr

Details Substituted phenylacetic acid derivatives and process for the pr Substituted phenylacetic acid derivatives and process for the pr

1978-03-10

1979-07-17

Thomas, Jr., James O.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

26050111, 260448R, 424316, 424319, 424267, 42424855, 544107, 562440, 562459, 546239, A61K 3119, C07C 6520

Patent

active

041615387

ABSTRACT:
4-(2-Oxo- or hydroxyimino-cycloalkan-1-ylmethyl)phenylacetic acid derivative and nontoxic pharmaceutically acceptable salt thereof are useful as an anti-inflammatory agent. The above 2-oxo-compound may be prepared by (a) hydrolyzing and decarboxylating 4-(1-alkoxycarbonyl-2-oxocycloalkan-1-ylmethyl)phenylacetic acid ester derivative or (b) reacting p-halomethylphenylacetic acid ester derivative with an enamine of cycloalkanone and hydrolyzing the resulting product. And further, the above 2-hydroxyimino-compound may be prepared by (c) reacting 4-(2-oxocycloalkan-1-ylmethyl)phenylacetic acid derivative (the product of process (a) or (b)) with hydroxylamine or (d) reacting a dilithium salt of cycloalkanone oxime with p-halomethyl- or p-sulfonyloxymethyl-phenylacetic acid ester derivative and hydrolyzing the resulting product.

REFERENCES:
patent: 3825587 (1974-07-01), Diamond et al.
patent: 3864384 (1975-02-01), Diamond et al.
patent: 3894080 (1975-07-01), Diamond et al.
patent: 4008269 (1977-02-01), Diamond et al.
patent: 4031133 (1977-06-01), Maillard
Maillard, Chemical Abstracts, 83, 43056(d), 1975.
Maillard, Chemical Abstracts, 78, 147578(p), 1973.

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