Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1993-12-15
1995-09-19
Dees, Jose G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
546290, 5483164, 548469, 548541, 549 33, 549416, 549475, 564 80, 564 82, 564 83, 564 84, 564 85, 564 86, 564 87, 564 88, 564 89, 564 90, 564 92, 564 96, 564 99, C07D45500, C07D30710, C07C31101
Patent
active
054516773
ABSTRACT:
Substituted phenylsulfonamides are selective .beta..sub.3 adrenergic receptor agonists with very little .beta..sub.1 and .beta..sub.2 adrenergic receptor activity and as such the compounds are capable of increasing lipolysis and energy expenditure in cells. The compounds thus have potent activity in the treatment of Type II diabetes and obesity. The compounds can also be used to lower triglyceride levels and cholesterol levels or raise high density lipoprotein levels or to decrease gut motility. In addition, the compounds can be used to reduced neurogenic inflammation or as antidepressant agents. The compounds are prepared by coupling an aminoalkylphenyl-sulfonamide with an appropriately substituted alkyl epoxide. Compositions and methods for the use of the compounds in the treatment of diabetes and obesity and for lowering triglyceride levels and cholesterol levels or raising high density lipoprotein levels or for increasing gut motility are also disclosed.
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Fisher Michael H.
Mathvink Robert J.
Ok Hyun O.
Parmee Emma R.
Weber Ann E.
Dees Jos,e G.
Jones Dwayne C.
Merck & Co. , Inc.
Rose David L.
Yang Mollie M.
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