Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Patent
1974-09-30
1978-08-08
Thomas, Jr., James O.
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
26029364, 26029378, 42424856, 424267, C07D41306, C07D21128, A61K 31535, A61K 31445
Patent
active
041058496
ABSTRACT:
The present invention relates to compounds of the formula ##STR1## having the [(X-substituted)phenyl]phenylmethyl moiety attached to the 2, 3, or 4 position of the piperidine ring and wherein X is hydrogen, halo, trifluoromethyl, (lower alkyl) containing 1-7 carbon atoms, or (lower alkoxy) containing 1-7 carbon atoms, A represents alkylene containing 1-3 carbon atoms, and R.sub.1 and R.sub.2 represent (lower alkyl) containing 1-7 carbon atoms or R.sub.1 and R.sub.2 together with N represent piperidino or morpholino and the pharmaceutically acceptable salts thereof. The compounds of this invention are prepared by the reaction of an appropriate [(X-substituted)phenyl]phenylmethylpiperidine with an appropriate 1-halo-2-dialkylaminoalkane. The compounds of this invention are useful as anti-arrythmic agents.
REFERENCES:
patent: 3081303 (1963-03-01), Rorig
patent: 3806526 (1974-04-01), Carr
patent: 3862173 (1975-01-01), Carr
patent: 3878217 (1975-04-01), Carr
Hamilton Robert W.
Rorig Kurt J.
G. D. Searle & Co.
McDonnell John J.
Shippen Michael
Thomas, Jr. James O.
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