Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-11-01
1995-10-31
Higel, Floyd D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514 13, 514 14, 514 15, 514 16, 514 17, 514 18, 514 19, 514252, 514318, 514332, 514340, 514343, 514346, 514347, 514351, 514521, 514520, 514570, 5142395, 5142392, 5142388, 5142378, 5142335, 5142328, 548250, 548252, 562463, 562466, 562469, 562471, A61K 3119, A61K 3141, C07D25704, C07D31124, C07C 5968, C07C 6524
Patent
active
054629543
ABSTRACT:
Antagonists having a substituted phenyl phenol or a substituted phenolic biphenyl structure, and various derivatives thereof, are specific leukotriene antagonists. Their structures, use and synthesis are disclosed. Also, pharmaceutical formulations are disclosed for use in applications treating diseases or conditions characterized by excessive release of leukotriene B.sub.4, one of the metabolites of arachidonic acid.
The primary LTB.sub.4 antagonistic structures are represented as: ##STR1##
REFERENCES:
patent: 3652645 (1972-03-01), Leigh et al.
patent: 3671580 (1972-06-01), Shen et al.
patent: 3755603 (1973-08-01), Harrison et al.
patent: 3882148 (1975-05-01), Augstein et al.
patent: 3972934 (1976-08-01), Marshall
patent: 4136192 (1979-01-01), Buckle et al.
patent: 4153807 (1979-05-01), Adams et al.
patent: 4219668 (1980-08-01), Chiccarelli et al.
patent: 4252817 (1981-02-01), Closse et al.
patent: 4281008 (1981-07-01), Chamberlain et al.
patent: 4424231 (1984-01-01), Bantick et al.
patent: 4474788 (1984-10-01), Bantick
patent: 4499299 (1985-02-01), Bernstein et al.
patent: 4507498 (1985-03-01), Carson et al.
patent: 4565882 (1986-01-01), Miyano et al.
patent: 4567184 (1986-01-01), Musser et al.
patent: 4567279 (1986-01-01), Chan
patent: 4650812 (1987-03-01), Cohen et al.
patent: 4661505 (1987-04-01), Marshall et al.
patent: 4665203 (1987-05-01), Miyano et al.
patent: 4820867 (1989-04-01), Belanger et al.
patent: 4853398 (1989-08-01), Carr et al.
patent: 4874777 (1989-10-01), Carr et al.
patent: 4899871 (1989-12-01), Djuric et al.
patent: 4945099 (1990-07-01), Bollinger et al.
patent: 4952705 (1990-08-01), Miyano et al.
patent: 4992576 (1991-02-01), Capinski
patent: 4996230 (1991-02-01), Gapinski
patent: 5004743 (1991-04-01), Young et al.
patent: 5087634 (1992-02-01), Reitz et al.
Therapeutic Patents Fast Alert, 2(17), AG20 (1991).
Buckle, et al., II, J. Med. Chem., 22(2), 158 (1979).
Chemical Abstracts 68:60277j (1968) (Mitsubishi).
LeMahieu, et al., J. Med. Chem., 30(1), 173 (1987).
Krell, et al., Advances in Prostaglandin, Thromboxane, and Leukotriene Research, 20, B. Sameulsson, et al., (Raven Press Ltd., New York 1990), p. 119.
Shaw, et al., J. Med. Chem., 34(4), 1235 (1991).
Konno, et al., II, Advances in Prostaglandin, Thromboxane, and Leukotriene Research, vol. 21, B. Sameulsson, et al., ed. (Raven Press, Ltd., New York 1990), p. 411.
Djuric et al., II, J. Med. Chem., 32(6), 1145 (1989).
"Leukotrienes and Lipoxygenase", J. Rokach, ed. (Elsevier, Amsterdam 1989), pp. 427-431 and 479-502 (Fitzsimmons et al.).
Siegel, et al., Monatsh., 88, 228 (1957).
Baker S. Richard
Dillard Robert D.
Floreancig Paul E.
Sawyer J. Scott
Sofia Michael J.
Benjamin Roger S.
Conrad Robert A.
Eli Lilly and Company
Higel Floyd D.
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