Substituted-phenyl (N,N'-cycloalkyl/alkyl carboxamide)-1H/3H-imi

Details Substituted-phenyl (N,N'-cycloalkyl/alkyl carboxamide)-1H/3H-imi Substituted-phenyl (N,N'-cycloalkyl/alkyl carboxamide)-1H/3H-imi

1992-11-24

1994-10-25

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 14, 544350, C07D47104, C07D47106

Patent

active

053590732

ABSTRACT:
A class of N,N'-cycloalkyl/alkyl benzamides of certain 1H-imidazo[4,5-b]pyridine and 3H-imidazo[4,5-b]pyridine compounds is described for treating cardiovascular and immuno-inflammatory related disorders mediated by platelet activating factor (PAF). Compounds of particular interest are those of the formula: ##STR1## wherein each of X.sup.a and X.sup.b is independently selected from nitrogen atom and --CH--, with the proviso that when one of X.sup.a and X.sup.b is selected as nitrogen atom, then the other of X.sup.a and X.sup.b must be --CH--; wherein R.sup.1 is selected from hydrido, alkyl, hydroxyalkyl, alkoxyalkyl, phenyl, halophenyl, alkylsilyloxyalkyl, amino, monoalkylamino, dialkylamino, aminoalkyl, monoalkylaminoalkyl and dialkylaminoalkyl; wherein each of R.sup.5, R.sup.6, R.sup.7 and R.sup.8 is independently selected from hydrido, hydroxy, alkyl, alkoxy, fluoro, chloro, bromo, haloalkyl, alkylthio, alkoxyalkyl, hydroxyalkyl, alkylthioalkyl, cyano, amino, monoalkylamino and dialkylamino; wherein each of R.sup.9 and R.sup.10 is independently selected from hydrido, alkyl, cycloalkyl, bicycloalkyl, heteroaryl, aryl, alkenyl and cycloalkenyl, and wherein any of said R.sup.9 and R.sup.10 substituents may be further substituted or a pharmaceutically-acceptable salt thereof.

REFERENCES:
patent: 4243671 (1981-01-01), Harris et al.
patent: 4284641 (1981-08-01), Thorogood
patent: 4357340 (1982-11-01), Thorogood
patent: 4416895 (1983-11-01), Thorogood
patent: 4579862 (1986-04-01), Manley et al.
patent: 4804658 (1989-02-01), Manley et al.
patent: 4914108 (1990-04-01), Khanna et al.
Kazutoshi Miyake, "Synthesis and Structure . . . ", XIIth International Symposium on Medicinal Chemistry, Sep. 1992.
CA 115: 49685j, "Preparation of N-Benzylbenzimidazole . . . " by Wittaker et al, 1991.

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