Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1976-11-11
1978-08-08
Trousof, Natalie
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
2602948G, 260295B, 260295AM, 548336, C07D23364
Patent
active
041058526
ABSTRACT:
This invention is directed toward pharmacologically active compounds of the formula ##STR1## wherein A represents a nitrogen atom which may be substituted by a methyl, cyclopropylmethyl, di(C.sub.1-4 alkyl)aminoethyl, methoxymethyl or hydroxyethyl group and B represents a carbonyl group or A and B together represent a grouping of the formula ##STR2## in which R.sup.a represents a hydrogen atom or a lower alkyl or hydroxymethyl group and X represents a nitrogen atom or C--R.sup.b wherein R.sup.b represents a hydrogen atom or a lower alkyl or hydroxymethyl group; R represents a halogen atom or a nitro or trifluoromethyl group; R.sup.1 represents a hydrogen atom or a lower alkyl group; R.sup.2 represents an acyl group derived from a naturally occurring amino acid (all such groups which contain an asymmetric carbon atom having the L- or D,L-configuration) and R.sup.3 represents a phenyl, halophenyl or 2-pyridyl group and acid addition salts thereof.
Also provided are methods for their preparation and intermediates thereof. These compounds exhibit activity as anticonvulsants, muscle relaxants and sedative.
REFERENCES:
patent: 3763179 (1973-10-01), Gall
patent: 3915981 (1975-10-01), Nakanshi et al.
patent: 3941803 (1976-03-01), Gall
Hassall Cedric H.
Johnson William H.
Krohn Antonin
Smithen Carey E.
Thomas William A.
Gould George M.
Hoffman Frank P.
Hoffmann-La Roche Inc.
Trousof Natalie
Welt Samuel L.
LandOfFree
Substituted phenyl ketones does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Substituted phenyl ketones, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted phenyl ketones will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-920407