Substituted phenoxyisobutyric acids and esters

Details Substituted phenoxyisobutyric acids and esters Substituted phenoxyisobutyric acids and esters

1994-04-19

1996-04-30

Chan, Nicky

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514572, 560 9, 560 53, 560 57, 560 61, 560 62, 560 63, 562426, 562464, 562468, 562471, 562472, A61K 31215, A61K 3139, C07C 69612, C07C 5911

Patent

active

055125956

ABSTRACT:
New substituted phenoxyisobutyric acids and esters that can be used as medicaments and correspond to the formula: ##STR1## wherein X, A, R, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and Z are as defined in the description.
Those compounds and their physiologically tolerable salts can be used therapeutically.

REFERENCES:
Role of Oxidized Low Density Lipoprotein in Atherogenesis by Witztum, et al., J. Clin. Invest. vol. 88, pp. 1785-1792 (Dec. 1991).
Malondialdehyde-modified Low Density Lipoproteins in Patients with Atherosclerotic Disease by Holvoet, et al., J. Clin. Invest., vol. 95, pp. 2611-2619 (Jun. 1995).
Increased Susceptibility to Lipid Oxidation of Low-Density Lipoproteins and Erythrocyte Membranes From Diabetic Patients by Rabini, et al., Metabolism, vol. 43, No. 12, pp. 1470-1474 (Dec. 1994).
Serum Antioxidants and Myocardial Infarction by Street, et al., American Heart Association, Inc., pp. 1154-1161 (1994).
Antioxidant vitamins and coronary heart disease risk by Clifton, Division of Human Nutrition, Commonwealth Scientific and Industrial Research Organisation, Adelaide, Australia, Current Opinion in Lipidology 1995, 6:20-24.
Effect of Alpha-tocopherol on Restenosis after Angioplasty in a Model of Experimental Atherosclerosis by Lafont, et al., J. Clin. Invest., vol. 95, pp. 1018-1025 (Mar. 1995).
Immunization of low density lipoprotein (LDL) receptor-deficient rabbits with homologous malondialdehyde-modified LDL reduces atherogenesis by Palinski, et al., Proc. Natl. Acad. Sci. USA, vol. 92, pp. 821-825 (Jan. 1995) Medical Sciences.

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