Substituted phenoxyalkyl quaternary ammonium compounds as antiar

Details Substituted phenoxyalkyl quaternary ammonium compounds as antiar Substituted phenoxyalkyl quaternary ammonium compounds as antiar

1976-01-12

1977-08-09

Robinson, Allen J.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

A61K 3114

Patent

active

040411788

ABSTRACT:
Quaternary ammonium compounds such as [2-(4-amino-2,6-dibromophenoxy)ethyl]dimethyl (allyl) ammonium bromide are prepared by the reaction of a tertiary amine such as 3,5-dibromo-.beta.-dimethylamino-p-phenetidine with a substituted organic compound such as allyl bromide. The quaternary ammonium compounds are useful in alleviating or inhibiting cardiac arrhythmias when the quaternary ammonium compounds, or compositions comprising the same are administered to animals.

REFERENCES:
patent: 2895995 (1959-07-01), Willey et al.
patent: 3453313 (1969-07-01), Margot et al.
Huy, Brit. J. Pharmacol, 7 (1952) pp. 117-129.
Huy et al., Brit. J. Pharmacol, 9 (1954) pp. 471-475.
Jones et al. Biochem. J., 45(1949) pp. 143-149.

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