Substituted phenoxy-aminopropanols

Details Substituted phenoxy-aminopropanols Substituted phenoxy-aminopropanols

1985-09-06

1987-03-10

Hines, Robert V.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514651, 549555, 549559, 549560, 564349, 568331, 568609, 568610, A61K 31135

Patent

active

046491600

ABSTRACT:
Substituted phenoxy-aminopropanols of the formula ##STR1## wherein R is a branched-chain alkyl of 3 or 4 carbon atoms, R.sup.1 is hydrogen, halogen or lower alkyl and R.sup.2 and R.sup.3, independently, are hydrogen, halogen, lower alkyl, lower alkoxy or lower alkylthio, and pharmaceutically acceptable acid addition salts thereof, are described. A process for their preparation, as well as pharmaceutical preparations containing them are also described. The compounds of formula I and their salts possess cardioselective .beta.-adrenergic blocking activity and antihypertensive activity.

REFERENCES:
patent: 3674840 (1972-07-01), Grandstrom et al.
patent: 3723476 (1973-03-01), Nakanishi et al.
patent: 3996382 (1976-12-01), Berntsson et al.
patent: 4252984 (1981-02-01), Manoury et al.

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