Substituted phenols and thiophenols useful as antioxidant agents

Details Substituted phenols and thiophenols useful as antioxidant agents Substituted phenols and thiophenols useful as antioxidant agents

1997-11-19

2000-09-05

Geist, Gary

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560130, 560135, 560144, 568 39, 568630, 568784, 514713, 514720, 514824, 514826, 514886, 514885, C07C 6702, C07C 5900, C07C 4100, A01N 3100

Patent

active

061145726

ABSTRACT:
The present invention provides compounds of the formula ##STR1## wherein X is selected from the group consisting of ##STR2## Y is thio, oxy or a methylene group; Z is hydrogen or --C(O)--(CH.sub.2).sub.m --Q wherein Q is hydrogen or --COOH and m is an integer 1, 2, 3 or 4;

REFERENCES:
patent: 3129262 (1964-04-01), Laufer
patent: 3246039 (1966-04-01), Relfschneider
patent: 3274257 (1966-09-01), Relfschneider
patent: 3303209 (1967-02-01), Relfschneider
patent: 3506674 (1970-04-01), Berger
patent: 3576883 (1971-04-01), Neuworth
patent: 3655773 (1972-04-01), Relfschneider
patent: 3751483 (1973-08-01), Cisney et al.
patent: 3786100 (1974-01-01), Neuworth
patent: 3801617 (1974-04-01), Fletcher
patent: 3839586 (1974-10-01), Ludvik
patent: 3853776 (1974-12-01), Clark et al.
patent: 3862332 (1975-01-01), Barnhart et al.
patent: 3897500 (1975-07-01), Neuworth
patent: 4379783 (1983-04-01), Melvin et al.
patent: 4388404 (1983-06-01), Morigaki et al.
patent: 4636573 (1987-01-01), Pastor
patent: 4663314 (1987-05-01), Hayase et al.
patent: 4670421 (1987-06-01), DeVries et al.
patent: 4719237 (1988-01-01), McCaughan
patent: 4734527 (1988-03-01), Krauss
patent: 4772363 (1988-09-01), Van Effen
patent: 4783495 (1988-11-01), Pastor
patent: 4861443 (1989-08-01), Van Effen
patent: 4870101 (1989-09-01), Ku et al.
patent: 4900757 (1990-02-01), Mao et al.
patent: 4904653 (1990-02-01), Strunk et al.
patent: 4975467 (1990-12-01), Ku et al.
patent: 5008421 (1991-04-01), Brownell et al.
patent: 5061734 (1991-10-01), Mao et al.
patent: 5112870 (1992-05-01), Mao et al.
patent: 5138012 (1992-08-01), Riding et al.
patent: 5155250 (1992-10-01), Parker et al.
patent: 5217870 (1993-06-01), Hession et al.
patent: 5272263 (1993-12-01), Hession et al.
patent: 5281738 (1994-01-01), Parker et al.
patent: 5304668 (1994-04-01), Parker et al.
patent: 5356917 (1994-10-01), Panetta
patent: 5367056 (1994-11-01), Hession et al.
patent: 5380747 (1995-01-01), Medford et al.
patent: 5393887 (1995-02-01), Pearch
patent: 5401883 (1995-03-01), Laskovics et al.
patent: 5574178 (1996-11-01), Tamura et al.
patent: 5606089 (1997-02-01), Tamura et al.
patent: 5663373 (1997-09-01), Tamura et al.
Robillard et al, J of Organic Chem., vol. 51, No. 10, 1986, pp 1700-1704.
John et al, Berichte Der Deutschen Chemiscren Gesellschaft, vol. 73, No. 9 (Sep. 4, 1940) pp 995-1001.
Gaertner et al, J of the American Oil Chemist Society, vol. 38, (Apr./1961) pp 212-215.
Gotteland et al, J. Med. Chem., 1995, 38, pp 3207-3216.
ilewski et al, Am. J.Respir. Cell Mol. Biol. vol. 12, pp 1-3, 1995.
Marui et al, American Society for Clinical Investigation, Inc. vol. 92, Oct., 1993, pp 1866-1874. Vascular Cell Adhesion Molecule-1.
Boschelli et al, J. Med. Chem. 1995, 38, pp 4597-4614. Inhibition of E-Selection-,ICAM-1-, and VCAM-1-.
Volin et al, FASEB Journal, Federation of American Societies for Experimental Biology, Mar. 10, 1995, vol.
Derwent Abstract, 94-322148/40 (B.17).
Derwent Abstract, 94-322152/40 (B.15).
Abstract 009, Pres. made at 211th ACS National Meeting, Mar. 24-28, 1996, Medicinal Chemical Divison, Ref. Bioorganic & Medicinal Chemistry Letter, vol. 6, pp 533-538, 1996.
Derwent Abstract, 94-325887/41 (B.11&12).
Alerting Bulletin 92-324750/49 Abbreviated Abstract for JP06505732-W (B.17).
Alerting Bulletin 92-332847/41 Abbreviated Abstract for JP06505735-W (B.13).
Parthasarathy, et al, "Probucol inhibits oxidative modification of low density lipoprotein", J. Clin. Invest., Vo.
Product Labeling for Lorelco, Physician's Desk Reference, 42nd edition, (1988), Medical Economics Co., Inc., Oradell, N.J.
Steinberg, "Studies on the Mechanism of Action of Probucol", The American Journal of Cardiology, vol. 57, pp 16H-21H.
Satonin et al, "Comparison of gas chromatography and high-performance liquid chromatography for the analysis of probucol in plasma" Journal of Chromatography, 380 (1986) pp 401-406.
Mao et al, "Monoclonal Antibodies to human . . . I", Clinical Chemistry, vol. 29, No. 11, 1983, pp 1890-1897.
Mao et al, "Monoclonal Antibodies to human . . . II", Clinical Chemistry, vol. 29, No. 11, 1983 pp 1898-1903.
Miller, "High Density Lipoproteins and Atherosclerosis", Ann. Rev. Med. 1980 31:97-108.
Brown et al, Lipoprotein Metabolism in the Macrophage: Implications for Cholesterol Deposition in Atheros.
Maciejko et al, "Apolipoprotein A-1 as a marker of angiographically assessed coronary-artery disease", The New England Journal of Medicine, 309:385-389 (Aug. 18, 1983).
Mao et al, "Immunochemistry oif human plasma high density lipoproteins . . . " Biochemistry, 1975, 14, pp 4127.
Badimon et al, "Quantification and immunolocalization of apolipoprotein E . . . ", Atherosclerosis, 61 (1986) 57-66.
Mao et al, "Immunochemistry of human plasma high density lipoproteins . . . ", Biochemistry, vol. 14, No. 18, 1975, pp 4127-4131.
Kita et al, "Probucol prevents the priogression of atherosclerosis in Watanabe heritable . . . " Medical Sciences, vol. 84, pp. 5928-5931, Aug. 1987.
Carew et al, "Antiatherogenic effect of probucol unrelated to its hypocholesterolemic effect . . . " Medical Sciences, vol. 84, pp 7725-7729, Nov., 1987.
Physician's Desk Reference, 44th edition, 1990, Medical Economics Co., Inc., Oradell, New Jersey.
Chemical Abstracts, vol. 108 (1988), 16125d: Proc. Natl. Acad. Sci. USA. 1987, 84(21), 7725-9.
S.J.T. Mao, et al., J. of Medicinal Chemistry 34, 298-302 (1991). From Mao.
S.J.T. Mao et al., Arteriosclerosis and Thrombosis, vol. 11, No. 5, pp. 1266-1275 (1991) From Mao.
R.L. Jackson et al., Hypercholesterolemia, Hypocholesterolemia, Hypertriglyceridemia, Plenum Press, NY pp 367-372 (1990) From Mao.
J. L. Witztum, Hypercholesterolemia, Hypocholesterolemia, Hypertriglyceridemia, Plenum Press, NY pp 353-365 (1990) From Mao.
M. Aviram, Artherosclerosis 98 (1993) 1-9. From Mao.
S.R. Srinivasan et al., Hypercholesterolemia, Hypocholesterolemia, Hypertriglyceridemia, Plenum Press, NY pp 373-381 (1990) From Mao.
Chemical abstracts online printout; 66:65162, rn = 13537-63-8, Kheifits et al.

Affiliated with

Also associated with

Rating

Substituted phenols and thiophenols useful as antioxidant agents does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Substituted phenols and thiophenols useful as antioxidant agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted phenols and thiophenols useful as antioxidant agents will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2213934