Substituted phenols and their use for the treatment of disorders

Details Substituted phenols and their use for the treatment of disorders Substituted phenols and their use for the treatment of disorders

1995-05-01

1996-05-21

Haley, Jacqueline

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5142395, 514255, 514329, 514400, 514567, 514641, 540605, 544164, 544382, 546223, 560 39, 564251, 564274, A61K 3141, A61K 31535, C07D29530

Patent

active

055190189

ABSTRACT:
Substituted phenols of the formula I ##STR1## processes for their preparation and compositions containing substituted phenols of the formulae I and II ##STR2## for the treatment of disorders caused by cell proliferation, such as psoriasis, tumor disorders and immunological disorders, are described.

REFERENCES:
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patent: 4833164 (1989-05-01), Batt
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Cushman et al., Synthesis and Evaluation of New Protein-Tyrosine Kinase Inhibitors. Part 2. Phenylhydrazones., Bioorganic & Medicinal Chemistry Letters, 1(4):215-218 (1991).
J. March, "Advanced Organic Chemistry," pp. 1084-1085. (1976).
H. Beyer, "Lehrbuch der Organischen Chemie," p.481 (1984).
Mattar et al., "Inhibition of the Epidermal Growth Factor Receptor Tyrosine Kinase Activity by Leflunomide," FEBS Letters, 334(2): 161-164 (1993).
Yoneda et al., "The Antiproliferative Effects of Tyrosine Kinase Inhibitors Tyrphostins on a Human Squamous Cell Carcinoma" in Vitro and in Nude Mice, Cancer Research, 51:4430-4435 (1991).

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