Substituted phenethylsulfones and method of reducing TNF.alpha.

Details Substituted phenethylsulfones and method of reducing TNF.alpha. Substituted phenethylsulfones and method of reducing TNF.alpha.

1999-06-29

2000-01-04

Stockton, Laura L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548210, A61K 31425, C07D27506

Patent

active

060110503

ABSTRACT:
Phenethylsulfones substituted in the position .alpha. to the phenyl group with a 1-oxoisoindoline or 1,3-dioxoisoindoline group reduce the levels of TNF.alpha. in a mammal. Typical embodiments are 2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-aminoisoindoline- 1,3-dione and 2-[1-(3-cyclopentyloxy-4-methoxyphenyl)-2-methylsulfonylethyl]isoindoline- 1,3-dione.

REFERENCES:
patent: 5236917 (1993-08-01), Dunlap et al.

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