Substituted oxotremorine derivatives and pharmaceutical use ther

Details Substituted oxotremorine derivatives and pharmaceutical use ther Substituted oxotremorine derivatives and pharmaceutical use ther

1991-04-24

1994-10-18

Springer, David B.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Silicon containing doai

514326, 514443, 548544, 548519, 548520, 548424, 546 14, 546208, A61K 31675, A61K 31040, C07D40106, C07D20708

Patent

active

053568850

ABSTRACT:
This disclosure describes novel substituted oxotremorine derivatives of formula I having nitrogen, oxygen or sulfur groups and the prodrug forms of these derivatives. The compounds have cholinergic activity. Also disclosed are methods for treating diseases of the central nervous system in mammals employing the compounds, pharmaceutical preparations containing the compounds and the processes for the production of the compounds. ##STR1##

REFERENCES:
patent: 3920824 (1975-11-01), Rajadhyaksha
patent: 4065471 (1977-12-01), Dickinson
patent: 4937235 (1990-06-01), Trybulski et al.
J. Levy et al., Therapie, 22(3): 671-688 (Jan. 1967).
F. Ehlert et al., Mol. Pharmacology, 28: 107-119 (1985).
Ringdahl, B., Eur. J. Pharmacol., 99: 177-184 (1984).

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