Substituted oxindole derivatives as tyrosine kinase inhibitors

Details Substituted oxindole derivatives as tyrosine kinase inhibitors Substituted oxindole derivatives as tyrosine kinase inhibitors

2005-06-09

2008-03-04

Shameem, Golam M. M. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S277700, C548S138000, C548S483000, C548S484000, C548S472000, C514S363000, C514S418000

Reexamination Certificate

active

07338966

ABSTRACT:
The present invention is related to oxindole derivatives of structure (I), compositions containing the same, and methods of use and manufacture of the same. Such compounds generally are useful pharmacologically as agents in those disease states alleviated by the alteration of mitogen activated signaling pathways in general, and in particular in the inhibition or antagonism of protein kinases, which pathologically involve aberrant cellular proliferation. Such disease states include tumor growth, restenosis, atherosclerosis, pain and thrombosis. In particular, the present invention relates to a series of substituted oxindole compounds, which exhibit Trk family protein tyrosine kinase inhibition, and which are useful in cancer therapy and chronic pain indications.

REFERENCES:
patent: 6350747 (2002-02-01), Glennon et al.
patent: 6369086 (2002-04-01), Davis et al.
patent: 6387919 (2002-05-01), Davis et al.
patent: 6492398 (2002-12-01), Vyas
patent: 6498176 (2002-12-01), Lackey et al.
patent: 6541503 (2003-04-01), Davis et al.
patent: 6620818 (2003-09-01), Davis
patent: 6624171 (2003-09-01), Harris et al.
patent: 6818632 (2004-11-01), Glennon et al.
patent: 7071217 (2006-07-01), Dickerson et al.
patent: 198 24 922 (1999-12-01), None
patent: 99/15500 (1999-04-01), None
patent: 00/56710 (2000-09-01), None
patent: 03/027111 (2003-04-01), None
Kamel, Mohamed, et al., “Monoazo metal complex forming dyes. V. Dyes derived from isatin,” Chemical Abstracts, vol. 67, No. 8, abstract No. 33812 (Aug. 12, 1967).

Affiliated with

Also associated with

Rating

Substituted oxindole derivatives as tyrosine kinase inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Substituted oxindole derivatives as tyrosine kinase inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted oxindole derivatives as tyrosine kinase inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3972321