Substituted oxazoles and thiazoles as hPPAR alpha agonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C548S203000, C548S204000, C548S235000, C548S236000, C514S374000

Reexamination Certificate

active

07091225

ABSTRACT:
Compounds of formula (I) and pharmaceutically acceptable salts, solvates and hydrolysable esters thereof wherein X is O or S X1 is O or S; X is S or O; R1 and R2 are independently H, methyl, or halogen; R4 and R5 are independently H or C1-3 alkyl or R4 and R5 may, together with the carbon atom to which they are bonded, form a 3–5 membered cycloalkyl ring; R6 and R7 are independently H, C1-3 alkyl, or allyl; each R3 is independently halogen, C1-6 straight or branched alkyl, or CF3; and y is 0, 1, 2, 3, 4 or 5 act as hPPAR alpha agonists.

REFERENCES:
patent: 6518290 (2003-02-01), Sierra
patent: 6706717 (2004-03-01), Barrish et al.
patent: 6710063 (2004-03-01), Chao et al.
patent: 6723740 (2004-04-01), Chao et al.
patent: 1 067 109 (2001-10-01), None
patent: 01/00603 (2001-04-01), None
patent: 01/40207 (2001-07-01), None

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