Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1992-04-06
1994-05-03
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514218, 514252, 514255, 514318, 514327, 514331, 540575, 540597, 540604, 540609, 544 34, 544 41, 544360, 544383, 544396, 544397, 546194, 546216, 546232, 546333, 546334, A61K 31435, A61K 31495, A61K 3155, C07D29513
Patent
active
053088409
ABSTRACT:
Aminophenol derivatives of the following formula (I) ##STR1## wherein X is hydrogen atom, lower alkyl or a protecting group for phenolic hydroxy, Y is hydrogen atom or lower alkyl, Z is hydrogen atom, lower alkyl, halogen atom or trifluoromethyl, A is hydrogen atom or lower alkyl, t is an integer of 1 to 5, l and m are respectively an integer of 2 to 4, E and W are nitrogen atoms, F is a direct bond or oxygen atom, P and Q are each hydrogen atom, halogen atom, lower alkyl or lower alkoxy, and R.sup.8 is hydrogen atom, hydroxy or a hydroxy-protecting group, and their pharmcologically acceptable salts. Since the aminophenol derivatives (I) of the present invention have excellent antioxidative action and antiinflammatory and antiallergic action in mammalian animals including human, they are extremely useful as pharmaceuticals such as an antiinflammatory or an antiallergic.
REFERENCES:
patent: 4929618 (1990-05-01), Koda et al.
patent: 5028610 (1991-07-01), Hirai et al.
patent: 5070087 (1991-12-01), Teng et al.
Teraji et al., CA 95:150706K (1981).
Carlson et al., Agents and Actions, vol. 26, No. 314, pp. 319-328 (1989).
Uchiyama et al., Analytical Biochemistry, vol. 86, pp. 271-278 (1978).
Akaboshi Fumihiko
Fukaya Chikara
Gotoh Tomokazu
Kajii Masahiko
Kondoh Takao
Datlow Philip
Green Cross Corporation
Shah Mukund J.
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