Substituted nitrogen-containing heterobicycles, the...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S266200, C514S266400, C544S284000, C544S293000

Reexamination Certificate

active

07429597

ABSTRACT:
The present invention relates to new substituted nitrogen-containing heterobicyclic compounds of general formulawherein B, X1to X3and R1to R5are defined as in claim1,the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties.The compounds of the above general formula I as well as the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, and their stereoisomers have valuable pharmacological properties, particularly an antithrombotic activity and a factor Xa-inhibiting activity.

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Flavia Messina, et al; Stereoselective Synthesis of α-aryl-2-Benzofuranmethanamines and α-aryl-1 H-indole-2-methanamines Through Pallladium-Mediated Annulation of Chiral α-arylpropargylamines; Tetrahedron Asymmetry (2000) vol. 11 pp. 1681-1685.
R. Marshall Wilson, et al; Synthesis and Chemistry of a Stabilized Dehydrosecodine Model System; Journal of Organic Chemistry (1981) vol. 46 pp. 3293-3302.

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