Substituted naphthyl indole derivatives as inhibitors of...

Details Substituted naphthyl indole derivatives as inhibitors of... Substituted naphthyl indole derivatives as inhibitors of...

2005-09-06

2005-09-06

Shameem, Golam M M (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S243000, C548S252000, C548S413000, C548S414000, C548S491000, C549S356000, C549S414000, C514S414000, C514S415000

Reexamination Certificate

active

06939886

ABSTRACT:
This invention provides PAI-1 inhibiting compounds of Formula I:wherein: R1, R2, R3, and R4are each H, alkyl, alkanoyl, halo, OH, aryl optionally substituted with R8, perfluoroalkyl, alkoxy, amino, alkylamino, dialkylamino, perfluoroalkoxy; R5is H, alkyl, perfluoroalkyl, aryl optionally substituted with R8, alkanoyl, aroyl optionally substituted with R8; R6is H, alkyl, alkylaryl, benzyl optionally substituted with R8, alkanoyl, aroyl optionally substituted with R8; R7is H, alkyl, alkylaryl, aryl optionally substituted with R8; n is 0-6; A is COOH, or an acid mimic such as tetraazole, SO3H, PO3H2, tetronic acid, etc.; R8is H, alkyl, cycloalkyl, alkanoyl, halo, OH, perfluoroalkyl, alkoxy, amino, alkylamino, dialkylamino, perfluoroalkoxy; or a pharmaceutically acceptable salt thereof; as well as pharmaceutical compositions and methods of treatment using these compounds.

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