Organic compounds -- part of the class 532-570 series – Organic compounds – Nitriles
Patent
1985-04-18
1986-05-20
Torrence, Dolph H.
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitriles
560 56, 562467, C07C12175, C07C 6336
Patent
active
045900108
ABSTRACT:
6-Alkoxy-5-trifluoromethyl-1-naphthoic acids are prepared by (1) cyanating a 6-alkoxytetralone so as to form a 6-alkoxy-1-cyano-3,4-dihydronaphthalene, (2) converting the 6-alkoxy-1-cyano-3,4-dihydronaphthalene to a naphthoic acid precursor selected from a 6-alkoxy-1-cyanonaphthalene and a hydrocarbyl 6-alkoxy-1-naphthoate, (3) halogenating the naphthoic acid precursor to the corresponding 5-halo derivative, (4) trifluoromethylating the 5-halo derivative to replace the 5-halo substituent with a 5-trifluoromethyl group, and (5) hydrolyzing the resultant product to a 6-alkoxy-5-trifluoromethyl-1-naphthoic acid. In a preferred embodiment of the invention, the process is conducted so as to prepare 6-methoxy-5-trifluoromethyl-1-naphthoic acid, which, like the other products, is known to be useful as a pharmaceutical intermediate.
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Davidson Robert I.
Maloney John R.
Ramachandran Venkataraman
Ethyl Corporation
Hogan Patricia J.
Johnson Donald L.
Sieberth John F.
Torrence Dolph H.
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