Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Patent
1986-06-25
1988-04-12
Hoke, Veronica P.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
514415, 514443, 514469, 514822, 514826, 514851, 514853, 514854, 514855, 514906, 548516, 549 51, 549469, 560 22, 560 43, 560139, 560173, C07C 6994, C07C10104, C07D20908, C07D33352, C07D30786
Patent
active
047375191
ABSTRACT:
The present invention provides certain novel substituted naphthalenes, indoles, benzofurans, and benzothiophenes of Formula I which are useful as inhibitors of leukotriene biosynthesis and as inhibitors of lipoxygenase. They are thus employed wherever it is medically necessary or desirable to inhibit these systems. ##STR1##
REFERENCES:
patent: 2917502 (1959-12-01), Schwyzer et al.
patent: 3948958 (1976-04-01), Rapoport et al.
patent: 4035512 (1977-07-01), Sugihara et al.
patent: 4199531 (1980-04-01), Terao et al.
patent: 4320065 (1982-03-01), Dotz
patent: 4358461 (1982-11-01), Maki et al.
patent: 4374775 (1983-02-01), Dotz
patent: 4388312 (1983-06-01), Terao et al.
patent: 4393075 (1983-07-01), Terao et al.
patent: 4617407 (1986-10-01), Young et la.
W. D. Wulff et al., Abstracts 88 and 89, American Chemical Society Meeting, Washington, D.C. (Aug. 18-19, 1983).
K. H. Dotz et al., XXIV Synthese von Naphthol-Derivaten Aus Carbonyl-Carben-Komplexen und Alkinen: Regioselektiver Einbau Des Alkins in Das Naphthalin-Gerust, J. of Organometal. Chem., 247:187-201 (1983).
K. Buggle et al., Decomposition Products of Pyrazolines Formed from 3-Alkylthioinden-1-Ones and Diazomethane, J. Chem. Soc. Perkin Trans., I, 572-575 (1975).
K. H. Dotz, IX Carbenliganden, Carbonylliganden und Alkine Als Bausteine fur Isocyclische und Heterocyclische Systeme, J. Organomet. Chem., 140(2):177-186 (1977).
K. H. Dotz et al., Templat-Reaktionen an Chrom(O): Stereoselektive Synthese Komplexgebundener Substituierter Naphthaline, Chem. Ber., 110:1555-1563 (1977).
C. D. Snyder et al., Synthesis of Menaquinone, J. Am. Chem. Soc., 96(26):8046-8054 (1974).
F. M. Dean et al., Spirans, Part 11, A New Method for Generating O-Quinone Methides, and Its Applications to the Synthesis of Spirochromans, J. Chem. Soc., Perkin Trans. I, 2289-2294 (1977).
O. Goncalves de Lima et al., Atividade Antimicrobiana Dos Compostos Intermediarios E Do Produto de Sintese 7-Metoxi-3,9-Dimetil-1-Oxafenaleno, Rev. Inst. Antibiot., Univ. Recife, 5N(1/2):3-9 (1963).
K. H. Dotz et al., Templat-Reaktionen an Chrom(O): Stereoselektive Synthese Kondensierter Aromatischer Liganden aus Pentacarbonyl-Carben-Chrom-Komplexen und Alkinen, Chem. Ber., 111:2517-2526 (1978).
J. G. Widdicombe, Control of Secretion of Tracheobronchial Mucus, Brit. Med. Bull., 34:57-61 (1978).
Z. Marom et al., Slow-Reacting Substances, Leukotrienes C.sub.4 and D.sub.45 Increase the Release of Mucus from Human Airways in vitro, Am. Rev. Respir. Dis., 126:449-451 (1982).
S. J. Coles etal., Effects of Leukotrienes C.sub.4 and D.sub.4 on Glycoprotein and Lysozyme Secretion by Human Bronchial Mucosa, Prostaglandins, 25(No. 2):155-170 (1983).
H. G. Johnson et al., Leukotriene-C.sub.4 Enhances Mucus Production from Submucosal Glands in Canine Trachea in Vivo, Int. J. Immunopharmacol., 5(No. 5):391-396 (1983).
H. G. Johnson et al., Secretogogue Responses of Leukotriene C.sub.4, D.sub.4 : Comparison of Potency in Canine Trachea in Vivo, Prostaglandins, 25(No. 2):237-243 (1983).
Z. Marom et al., Effects of Arachidonic Acid, Monohydroxyeicosatetraenoic Acid and Prostaglandins on the Release of Mucous Glycoproteins from Human Airways in Vitro, J. Clin. Invest., 67:1695-1702 (1981).
A. C. Peatfield et al., The Effect of Leukotriene C.sub.4 on Mucin Release into the Cat Trachea in vivo and in vitro, Br. J. Pharmac., 77:391-393 (1982).
J. H. Shelhamer et al., The Effects of Arachinoids and Leukotrienes on the Release of Mucus from Human Airways, Chest 81:36S-37S (1982).
O. Cromwell et al., Identification of Leukotrienes D and B in Sputum from Cystic Fibrosis Patients, The Lancet, Jul. 25, 1981, pp. 164-165.
T. Ahmed et al. Abnormal Mucociliary Transport in Allergic Patients with Antigen-Induced Bronchospasm: Role of Slow Reacting Substance of Anaphylaxis, Am. Rev. Respir. Dis., 124:110-114 (1981).
M. Hamberg et al., Prostaglandin Endoperoxides, Novel Transformations of Arachidonic Acid in Human Platelets, Proc. Nat. Acad. Sci., USA, 71(No. 9):3400-3404, Sep. 1974.
M. Shiraishi et al., Studies on the Synthesis of 5-Lipoxygenase Inhibitors, J. Pharm. Dyn., 7(No. 5): s-95 (1984).
M. Shiraishi and S. Terao, Quinones, Part 3, Synthesis of Quinone Derivatives Having Ethylenic and Acetylenic Bonds: Specific Inhibitors of the Formation of Leukotrienes and 5-Hydroxyicosa-6,8,11,14-Tetraenoic Acid (5-HETE), J. Chem. Soc. Perkin Trans. I, 1591-1599 (1983).
Johnson Herbert G.
Yamashita Ayako
Cox Martha A.
Hoke Veronica P.
The Upjohn Company
LandOfFree
Substituted naphthalenes, indoles, benzofurans, and benzothiophe does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Substituted naphthalenes, indoles, benzofurans, and benzothiophe, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted naphthalenes, indoles, benzofurans, and benzothiophe will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1429627