Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-07-11
2006-07-11
Morris, Patricia L. (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S348000, C514S349000, C546S286000, C546S287000, C546S296000, C546S297000, C546S298000, C546S299000
Reexamination Certificate
active
07074813
ABSTRACT:
The present invention is directed to substituted N′-(arylcarbonyl)-benzhydrazides, N′-(arylcarbonyl)-benzylidene-hydrazides and analogs thereof, represented by the Formulae I and II:wherein Ar1, Ar2, and R1–R2are defined herein. The present invention also relates to the discovery that compounds having Formulae I and II are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
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Cai Sui Xiong
Drewe John
Kasibhatla Shailaja
Reddy P. Sanjeeva
Zhang Han-Zhong
Cytovia, Inc.
Morris Patricia L.
Sterne Kessler Goldstein & Fox P.L.L.C.
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