Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1977-11-17
1980-03-18
Lee, Mary C.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
2602452T, 2602452R, 26032614R, 26037625, 26037631, 424250, 424263, 424267R, 424270, 424272, 424273, 424274, 542416, 544144, 544238, 544282, 544373, 546 22, 546200, 546256, 548336, C07D48704, A61K 3140
Patent
active
041940474
ABSTRACT:
Disclosed are substituted N-methylene derivatives of thienamycin which may be represented by the following structural formula: ##STR1## wherein X and Y are selected from the group consisting of hydrogen, R, OR, SR, and NR.sup.1 R.sup.2 wherein, inter alia, R is substituted or unsubstituted: alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, heterocyclyl, and heterocyclylalkyl; R.sup.1 and R.sup.2 are hydrogen or R. Such compounds and their pharmaceutically acceptable salt, ether, ester and amide derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such compounds; pharmaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.
Christensen Burton G.
Leanza William J.
Wildonger Kenneth J.
Arno James A.
Lee Mary C.
Levitt Julian S.
Merck & Co. , Inc.
Pfeiffer Hesna J.
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