Substituted N-(indole-2-carbonyl) -amides and derivatives as...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S254090, C544S224000, C544S335000, C544S373000

Reexamination Certificate

active

06846820

ABSTRACT:
This invention relates to certain indole-2-carboxamides of formula (I) and the pharmaceutically acceptable salts and prodrugs thereof, wherein R6is carboxy, (C1-C8)alkoxycarbonyl, C(O)NR8R9or C(O)R12, useful as inhibitors of glycogen phosphorylase, methods of treating glycogen phosphorylase dependent diseases or conditions with such compounds and pharmaceutical compositions comprising such compounds.

REFERENCES:
patent: 4764610 (1988-08-01), Zimmerman
patent: 4836846 (1989-06-01), Zimmerman
patent: 4902708 (1990-02-01), Kim
patent: 4904846 (1990-02-01), Oscadal
patent: 4933325 (1990-06-01), Hansen, Jr. et al.
patent: 4997950 (1991-03-01), Murphy et al.
patent: 5034376 (1991-07-01), Hoover et al.
patent: 5064853 (1991-11-01), Gasc et al.
patent: 5089638 (1992-02-01), Freidinger
patent: 5128346 (1992-07-01), Nadzan et al.
patent: 5219859 (1993-06-01), Festal et al.
patent: 5250517 (1993-10-01), Branca et al.
patent: 5346907 (1994-09-01), Kerwin, Jr. et al.
patent: 5610144 (1997-03-01), Capet et al.
patent: 0080283 (1983-06-01), None
patent: 0288965 (1988-11-01), None
patent: 0336356 (1989-10-01), None
patent: 0405506 (1991-01-01), None
patent: 0431520 (1991-06-01), None
patent: WO 8803022 (1988-05-01), None
patent: WO 9100725 (1991-01-01), None
patent: WO 9102719 (1991-03-01), None
patent: WO 9112264 (1991-08-01), None
patent: WO 9113874 (1991-09-01), None
patent: WO 9320099 (1993-10-01), None
patent: WO 9406755 (1994-03-01), None
patent: WO 9407815 (1994-04-01), None
Martin, J.L. et al. “ Biochemistry” 1991, 30, 10101.
Kasvinsky, P. J. et al. “J. Biol. Chem.” 1978, 253, 3343-3351 and 9102-9106.
Blundell, T.B. et al. “ Diabetologia” 1992, 35, Suppl. 2, S69-S76.
Nadzan, A. M. et al. “ Design of Cholecystokinin Analogs with High Affinity and Selectivity for Brain CCK Receptors” pp. 100-102.
Chemical abstr., vol. 90, No. 19, May 7, 1979 (Columbus, Ohio, USA p. 587, column 2, the abstract No. 151917p, PIGULLA, J. et al., “Preparation of indole-2-carboxamides and esters of (indole-2-ylcarbonylamino)carboxylic acids by the imidazolide method.” Arch. Pharm. (Weinhem, Ger.) 1979, 312(1), 12-18 (Ger.).
Chemical Abstr., vol. 90, No. 2, Jan. 15, 1979 (Columbus, OH, USA), p. 636, column 1, the abstract No. 22858w, PIGULLA, J. et al., “Azepinoindoles, III. Cyclization of N-(2-indolycarbonyl)-β-amino acids to azepino(3,4-b)indolesdiones”, Justus Liebigs Ann. Chem. 1978, (9), 1390-8.
Allard, M. F. et al, “Am. J. Physiol.” 1994, 267, H66-H74.
Farris P. L. et al. ,Science 1984, vol. 226, pp. 1215-1217, “ Morphine Analgesia Potentiated but Tolerance Not Affected by Active Immunization Against Sholecystokinin”.
Bock, Mark G. et al. “J. Med. Chem.” 1989, 32, pp. 13-16, “Benzodiazepine Gastrin and Brain Cholecystokinin Receptor Ligands: L-365,260”.
Shroff, James R. et al. “J. Med. Chem.” 1982, 25, pp. 359-362, “Chemistry and Hypoglycemic Activity of N-(((Dialkylamino)alkoxy)phenyl)benzamidines”.
Burn, Peter et al, “J. Med. Chem.” 1982, 25, pp. 363-368, “Synthesis and Dopaminergic Properties of Some exo- and endo-2-Aminobenzonorbomenes Designed as Rigid Analogues of Dopamine”.
Wolfe, Christopher L., et al., Circulation, vol. 87, No. 3, “Loss of Myocardial Protection After Preconditioning Correlates with th Time Course of Glycogen Recovery within the Preconditioned Segment,” Mar. 1993.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Substituted N-(indole-2-carbonyl) -amides and derivatives as... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Substituted N-(indole-2-carbonyl) -amides and derivatives as..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted N-(indole-2-carbonyl) -amides and derivatives as... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3369425

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.