Substituted N-heteroaryl and N-aryl-1,2-diaminocyclobutene-3,4-d

Details Substituted N-heteroaryl and N-aryl-1,2-diaminocyclobutene-3,4-d Substituted N-heteroaryl and N-aryl-1,2-diaminocyclobutene-3,4-d

1994-10-02

1996-04-09

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514522, 5483365, 558414, A61K 31135, C07C 8750

Patent

active

055062520

ABSTRACT:
The compounds of the formula: ##STR1## wherein: R.sub.1 and R.sub.2 are, independently, hydrogen, straight or branched chain alkyl or mono- or bi-cyclic alkyl; A is a substituted phenyl group containing one cyano substituent and one substituent selected from cyano, nitro, alkyl, perfluoroalkyl, alkoxy, perfluoroalkoxy, amino, alkylamino, dialkylamino, sulfamyl, alkylsulfonamido, arylsulfonamido, alkylcarboxamido, arylcarboxamido, alkylsulfonyl, perfluoroalkylsulfonyl, arylsulfonyl, chloro, bromo, fluoro, iodo, 1-imidazolyl or carboxyl; or a pharmaceutically acceptable salt thereof, are smooth muscle relaxants.

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