Substituted N-heteroaryl-1,2-diaminocyclobutene-3,4-dione compou

Details Substituted N-heteroaryl-1,2-diaminocyclobutene-3,4-dione compou Substituted N-heteroaryl-1,2-diaminocyclobutene-3,4-dione compou

1996-02-14

1997-02-25

Davis, Zinna Northington

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514310, 514311, 514313, 514403, 546143, 546146, 546171, 546161, 546160, 5483625, C07D21302, A61K 3147, A61K 31415

Patent

active

056059094

ABSTRACT:
The compounds of formula I are smooth muscle relaxants: ##STR1## wherein R.sub.1 is hydrogen, alkyl, cycloalkyl, alkanoyl, alkylsulfonyl, aroyl, arylalkenoyl, arylsulfonyl, arylalkanoyl or arylalkylsulfonyl; R.sub.2 is hydrogen, alkyl or cyclic or bicyclic alkyl; A is selected from the following: ##STR2##

REFERENCES:
patent: 4390701 (1983-06-01), Algieri et al.
patent: 4673747 (1987-06-01), Nohara et al.
Tietze, et al., Squaric Acid Diethyl Ester: A New Coupling Reagent for the Formation of Drug Biopolymer Conjugates. Synthesis of Squaric Acid Ester Amides and Diamides, Chem. Ber., 124, p. 1215, 1991.
Tietze, et al., Conjugation of p-Aminophenyl Glycosides with Squaric Acid Diester to a Carrier Protein and the Use of Neoglycoprotein in the Histochemical Detection of Lectins, Bioconjugate Chem., 2, p. 148, 1991.
Ehrhardt, et al., Amide und Thioamide der Quadratsaure: Synthese und Reaktionen, Chem. Ber., 110, p. 2506, 1977.
Neuse, et al., Amidierung von Quadratsaure-estern, Liebigs Ann. Chem., p. 619, 1973.

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