Substituted N-carboxymethyl-aminoacylaminoalkanoic acids useful

Details Substituted N-carboxymethyl-aminoacylaminoalkanoic acids useful Substituted N-carboxymethyl-aminoacylaminoalkanoic acids useful

1983-05-16

1987-01-06

Ford, John M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546273, 514 11, 546274, 546122, 514 19, 546140, 546147, 514300, 546174, 546175, 514307, 548156, 548159, 514308, 548180, 548181, 514314, 548204, 548207, 514333, 548214, 548327, 514336, 548328, 548336, 514337, 548454, 548455, 514338, 548467, 548468, 514339, 548494, 548510, 514340, 548517, 548518, 514341, 548525, 548527, 514342, 548540, 2609982, 514367, 514365, 514372, 514373, 514394, 514397, 514419, 514415, 514422, 546256, 546281, 546280, 546278, 546268, 546269, 546270, 546271, 546272, C07D20709, C07D40104, C

Patent

active

046347160

ABSTRACT:
Compounds of the formula: ##STR1## where R.sup.3 is ##STR2## where n is 1-3 and the R.sup.a 's and R.sup.b 's are independently hydrogen or loweralkyl; and pharmaceutically acceptable salts thereof; are inhibitors or angiotensin I converting enzyme useful as antihypertensive agents.

REFERENCES:
patent: 4113715 (1978-09-01), Ondetti et al.
patent: 4129571 (1978-12-01), Ondetti et al.
patent: 4154960 (1979-05-01), Ondetti et al.
patent: 4374829 (1983-02-01), Harris et al.
Abstract of ACS Meeting of 9-11-78 entitled "Superactive Analogs of the Angiotensin Converting Enzyme Inhibitor BPP.sub.9a Containing L-3,4-Dehydroproline".
Patchett et al., in "A New Class of Angiotensin-Converting Enzyme Inhibitors", Nature, vol. 228, No. 5788, pp. 280-283 (Nov. 20, 1980).

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