Substituted N-benzoyl-N'-(2-phenylethyl)-piperazines

Details Substituted N-benzoyl-N'-(2-phenylethyl)-piperazines Substituted N-benzoyl-N'-(2-phenylethyl)-piperazines

1993-02-22

1994-06-14

Bernhardt, Emily

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544391, A61K 31495, C07D29516

Patent

active

053210271

ABSTRACT:
N-Benzoyl-N'-(2-phenylethyl)-piperazines of formula I ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 have the meanings as defined in the specification, and salts thereof, have analgesic properties and can be used as analgesic active ingredients in medicaments. They are prepared, for example, as follows: a compound of formula II ##STR2## wherein X.sub.1 is carboxy or reactive functionally modified carboxy, or a salt thereof, is reacted with a compound of formula III ##STR3## wherein X.sub.2 is hydrogen.

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Jacob et al. C.A. 58:3444e (1963) Rhone-Poulenc.
Jacob et al. C.A. 58:4583f (1963) Rhone-Poulenc.
Jacob et al. C.A. 58:10211g (1963) Rhone-Poulenc.

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