Substituted N-arylmethylamino derivatives of cyclobutene-3, 4-di

Details Substituted N-arylmethylamino derivatives of cyclobutene-3, 4-di Substituted N-arylmethylamino derivatives of cyclobutene-3, 4-di

1997-07-07

1998-07-14

Reamer, James H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514524, 514538, 514534, 514604, 514605, 514617, 514625, 514627, 514629, 514655, 560 27, 564 84, 564 90, 564 99, 564207, 564180, 564184, 564218, 564345, 564384, A61K 31275

Patent

active

057805059

ABSTRACT:
The compounds of the formula: ##STR1## wherein R.sub.1 is straight chain alkyl, branched chain alkyl, cycloalkyl, hydroxyalkyl, fluoroalkyl or polyfluoroalkyl; R.sub.7 and R.sub.8 are, independently, hydrogen or an acyl substituent selected from the group consisting of formyl, alkanoyl, alkenoyl, alkoxycarbonyl, alkylsulfonyl, aroyl, arylalkenoyl, arylsulfonyl, arylalkanoyl or arylalkylsulfonyl; A is a phenyl group with either two or three substituents of the following formula: ##STR2## wherein the positions of substitution are R.sub.2,R.sub.3 -, R.sub.2,R.sub.4 -, R.sub.2,R.sub.5 -, R.sub.2,R.sub.6 -, R.sub.3,R.sub.4 -, R.sub.3,R.sub.5 -, and R.sub.2,R.sub.4,R.sub.6 - and R.sub.2 is methyl, ethyl, fluoro, chloro, methoxy or trifluoromethyl; R.sub.3 is methyl, ethyl, fluoro, chloro, methoxy or trifluoromethyl; R.sub.4 is methyl, fluoro, bromo, methoxy or cyano; R.sub.5 is methyl, fluoro, chloro, methoxy, cyano or trifluoromethyl; R.sub.6 is methyl, fluoro, chloro, or methoxy; or a pharmaceutically acceptable salt thereof, relax smooth muscles.

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