Substituted N-arylmethyl and heterocylylmethyl-1H-pyrazolo[3,4-b

Details Substituted N-arylmethyl and heterocylylmethyl-1H-pyrazolo[3,4-b Substituted N-arylmethyl and heterocylylmethyl-1H-pyrazolo[3,4-b

1998-09-10

1999-12-28

Huang, Evelyn Mei

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5142328, 514253, 514256, 544115, 544238, 544333, 544405, 546 82, A61K 3147, A61K 31495, C07D21546, C07D47104

Patent

active

060082267

ABSTRACT:
Substituted N-arylmethyl and heterocyclylmethyl-1H-pyrazolo[3,4-b]quinolin-4-amines, pharmaceutical compositions containing them and methods for a) effecting c-GMP-phosphodiesterase inhibition, b) treating heart failure and/or hypertension, c) reversing or reducing nitrate-induced tolerance and d) treating angina pectoris, congestive heart disease and myocardial infarction utilizing them.

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