Substituted N-arylmethyl and heterocyclmethyl-1H-pyrazolo[3,4-b]

Details Substituted N-arylmethyl and heterocyclmethyl-1H-pyrazolo[3,4-b] Substituted N-arylmethyl and heterocyclmethyl-1H-pyrazolo[3,4-b]

1995-03-10

1997-03-25

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5142328, 544115, 546 82, A61K 3147, C07D21546, C07D47104

Patent

active

056145306

ABSTRACT:
Substituted N-arylmethyl and heterocyclylmethyl-1H-pyrazolo[3,4-b]quinolin-4-amines, pharmaceutical compositions containing them and methods for a) effecting c-GMP-phosphodiesterase inhibition, b) treating heart failure and/or hypertension, c) reversing or reducing nitrate-induced tolerance and d) treating angina pectoris, congestive heart disease and myocardial infarction utilizing them.

REFERENCES:
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Stein et al, J. Med. Chem. 1970, 13(10), 153-155.
Zikan et al, Chem. Abstracts 108:204613K 1988.
Zikan et al, Chem. Abstracts 106:138447q 1987.
Radl et al, Chem. Abstracts 106:18429P, 1987.
Radl et al, Chem. Abstracts 105:226434T 1986.
Crenshaw et al, J. Med. Chem., 1976, 19(2), 262-275.

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