Substituted N -acyl homoserine lactones

Details Substituted N -acyl homoserine lactones Substituted N -acyl homoserine lactones

2007-05-22

2011-11-01

Chandrakumar, Nizal (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

08049020

ABSTRACT:
The substituted N-acyl homoserine lactones have the formula (I) wherein R is a saturated or unsaturated straight chain or branched chain aliphatic hydrocarbyl group containing from 5 to 14 carbon atoms; R2is H or a 1-4C alkyl group; R3is H or F; and any enantiomer thereof. These compounds exhibit immunosuppressant activity while exhibiting reduced biosensor (autoinducer) activity compared to known N-acyl homoserine lactones.

REFERENCES:
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patent: 95/01175 (1995-01-01), None
patent: 01/74801 (2001-10-01), None
patent: WO 01/74801 (2001-11-01), None
Telford et al., ThePseudomonas aeruginosaQuorum-Sensing Signal Molecule N-(3-Oxododecanoyl)-L-Homoserine Lactone Has Immunomodulatory Activity. Infection and Immunity (1998) 66:36-42.

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