Substituted N-(1,2-dihydro-2-oxonicotinyl)-cephalexins and -ceph

Details Substituted N-(1,2-dihydro-2-oxonicotinyl)-cephalexins and -ceph Substituted N-(1,2-dihydro-2-oxonicotinyl)-cephalexins and -ceph

1974-11-11

1976-04-06

Rollins, Alton D.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602955R, 2602955T, 424246, C07D50134

Patent

active

039489035

ABSTRACT:
Novel organic amide compounds which are substituted N-(1,2-dihydro-2-oxonicotinyl)-ampicillins, -cephalexins and -cephaloglycins having broad spectrum antibacterial utility are provided by (a) reacting the free amino acid ampicillin, cephalexin or cephaloglycin or the acid salt or silylated derivative thereof with a reactive derivative of the corresponding 1,2-dihydro-2-oxonicotinic acid or (b) reacting the free amino acid 6-aminopenicillanic acid, 7-aminocephalosporanic acid or 7-amino-3-methylceph-3-em-4-carboxylic acid or the acid salt or silylated derivative thereof with a reactive derivative of the corresponding N-(1,2-dihydro-2-oxonicotinyl)-2-phenylglycine.

REFERENCES:
patent: 3308120 (1967-03-01), Takano et al.
patent: 3360515 (1967-12-01), Takano et al.
patent: 3433784 (1969-03-01), Long et al.

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