Substituted long chain alcohol xanthine compounds

Details Substituted long chain alcohol xanthine compounds Substituted long chain alcohol xanthine compounds

1992-11-16

1995-12-05

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen bonded directly to ring carbon of the purine ring...

514263, C07D47304, A61K 3152

Patent

active

054730708

ABSTRACT:
There is disclosed compounds and pharmaceutical compositions comprising compounds of the formula: ##STR1## wherein each of one or two R is independently ##STR2## wherein n is an integer from 7 to 20, at least one of X or Y is --OH and if one of X or Y is --OH then the other X or Y is H, CH.sub.3, CH.sub.3 --CH.sub.2, CH.sub.3 --(CH.sub.2).sub.2 --, or (CH.sub.3).sub.2 --CH.sub.2 --, and W.sub.1, W.sub.2, and W.sub.3 is independently H, CH.sub.3, CH.sub.3 --CH.sub.2, CH.sub.3 --(CH.sub.2).sub.2 --, or (CH.sub.3).sub.2 --CH.sub.2 --, and wherein the alkyl groups may be substituted by a hydroxyl, halo or dimethylamino group and/or interrupted by an oxygen atom, H or alkyl (1-4C), including resolved enantiomers and/or diastereomers, salts and mixtures thereof. In particular, the compounds lower elevated levels of unsaturated, non-arachidonate phosphatidic acid (PA) and diacylglycerol (DAG) derived from said PA within seconds of the primary stimulus and their contact with said cells. The modulatory effect depends on the nature of the target cell and the stimulus applied.

REFERENCES:
patent: 3737433 (1983-03-01), Mohler et al.
patent: 4515795 (1985-07-01), Hinze et al.
patent: 4599414 (1986-07-01), Sugimoto et al.
patent: 4612315 (1986-09-01), Jacobson et al.
patent: 4833146 (1989-05-01), Gebert et al.

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