Substituted kynurenines and process for their preparation

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...

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514540, 514541, 514676, A61K 3712, A61K 3744, A61K 3318

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active

057080305

ABSTRACT:
The present invention relates to the use in the treatment of cognitive disorders associated with the aging processes of the brain and perinatal brain disorders of compounds which act as inhibitors of the enzyme kynurenine aminotransferase (KAT).

REFERENCES:
Japanese Patent Application No. J8 2018-458 of Tanable SeiyakuKK (Abstract) Apr. 16, 1982.
Chemical Abstracts, vol. 93, 1980, 239866u.
J. Med. Chem., 1994, 37, 334-36.
Society for Neuroscience, vol. 19, 1993, Abstract 554.7.
Society for Neuroscience, vol. 18, 1992, Abstract 482.12.
Adv. in Enzym. 1979, 49, 1-40.
Chemical Abstracts, vol. 79, 1973, 28836g.
Chemical Abstracts AN 1992; 564604, Gramsberger et al, 1992.

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