Substituted isoxazole for the treatment of inflammation

Details Substituted isoxazole for the treatment of inflammation Substituted isoxazole for the treatment of inflammation

1997-02-18

1999-11-16

Stockton, Laura L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5462721, A61K 3144, C07D41304, C07D41306, C07D41312

Patent

active

059859024

ABSTRACT:
A class of substituted isoxazolyl compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula II ##STR1## wherein R.sup.1 is selected from hydroxyl, lower alkyl, carboxyl, lower carboxyalkyl, lower aminocarbonylalkyl, lower alkoxycarbonylalkyl, lower aralkyl, lower alkoxyalkyl, lower aralkoxyalkyl, lower alkylthioalkyl, lower aralkylthioalkyl, lower alkylaminoalkyl, lower aryloxyalkyl, lower arylthioalkyl, lower haloalkyl, lower hydroxylalkyl, cycloalkyl, cycloalkylalkyl, and aralkyl; wherein R.sup.3 is selected from cycloalkyl, cycloalkenyl, aryl, and heteroaryl; wherein R.sup.3 is optionally substituted at a substitutable position with one or more radicals independently selected from lower alkylsulfinyl, lower alkyl, cyano, carboxyl, lower alkoxycarbonyl, lower haloalkyl, hydroxyl, lower hydroxyalkyl, lower haloalkoxy, amino, lower alkylamino, lower arylamino, lower aminoalkyl, nitro, halo, lower alkoxy, aminosulfonyl, and lower alkylthio; and wherein R.sup.4 is selected from lower alkyl, hydroxyl and amino; or a pharmaceutically-acceptable salt thereof.

REFERENCES:
patent: 5310926 (1994-05-01), Hagiwara et al.
patent: 5318970 (1994-06-01), Suzuki et al.
Ichiro Yamawaki et al, Chem. Pharm. Bull., 36:3142-3146 (1988).
Umezawa et al, Cbem., vol. 36, No. 9, pp. 1150-1154, Sep. 1963.
Descamps et al, Bull. Soc. Chim. Belg., 73:459-482 (1964).

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