Substituted isocoumarins as serine protease inhibitors and anti-

Details Substituted isocoumarins as serine protease inhibitors and anti- Substituted isocoumarins as serine protease inhibitors and anti-

1992-06-17

1994-06-28

Robinson, Douglas W.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Enzyme inactivation by chemical treatment

435212, 435213, 435214, 435215, 435217, 435218, 435219, C12N 999, C12N 948, C12N 950, C12N 966

Patent

active

053246489

ABSTRACT:
Substituted isocoumarins, their use in inhibiting serine proteases with trypsin-like, chymotrypsin-like and elastase-like specificity and their roles as anti-inflammatory agents.

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patent: 4745116 (1988-05-01), Krantz et al.
patent: 5109018 (1992-04-01), Powers et al.
Hemmi et al., Biochemistry 24:1841-1848 (1985).
Kam et al., J. Am. Chem. Soc. 109:5044-5045 (1987).
Harper et al., J. Am. Chem. Soc. 106:7618-7619 (1984).
Harper et al., Biochemistry 24:7200-7213 (1985).
Hudig et al., BBRC 149:882-888 (1987).
Kam et al., Biochemistry 27:2547-2557 (1988).

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