Substituted indolizine 1,2,3,6,7,8 derivatives, FGFs...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C546S112000

Reexamination Certificate

active

07553845

ABSTRACT:
The invention is directed to a compound of formula I,wherein R, R1, R2, R3and R4are as defined herein, or a pharmaceutically acceptable salt thereof, and its pharmaceutically composition, preparation and uses as an inhibitor of FGFs (fibroblast growth factors).

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Chen et al., “FGFR1/Pi3K/AKT, etc.,” Journal of Cellular Biochemistry 101: 1492-1504 (2007).
Cao, “Antiangiogenic cancer therapy”, Seminars in Cancer Biology 14 (2004) 139-145.
Sathornsumette et al., “Antiangiogenic Therapy, etc.,” Current Pharmaceutical Design, 2007, 13, 3545-3558.
Kwabi-Addo et al., “The role of fibroblast, etc.,” Endocrine-Related Cancer (2004) 11 709-724.
Rosseels, et al., Study in the Indolizines Series. V. Effect of Indolizine Substitution i Position 1 in the Butoprozine Series, European J. of Med. Chemistry; 1983; 18(4); pp. 339-346.
Compounds for Screening, SPECS and bioSPECS XP002224380, Database Chemcats chemical abstracts service, Columbus, Ohio; Jul. 1, 2001.

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