Substituted indolinones

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C514S418000, C548S484000, C548S486000

Reexamination Certificate

active

06858641

ABSTRACT:
The present invention relates to indolinones substituted in the 6-position of general formulawhereinR1to R5and X are defined as in claim 1, the isomers and the salts thereof, particularly the physiologically acceptable salts thereof which have valuable pharmacological properties, in particular an inhibiting effect on various receptor tyrosine kinases and cyclin/CDK complexes and on the proliferation of endothelial cells and various, pharmaceutical compositions containing these compounds, their use and processes for preparing them.

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Stein, J. H. et al., Editor-in-Chief, Internal Medicine, 4th Edition, Chapters 71 and 72, 1994.*
Roth, G. J. et al, U.S. Appl. No. 10/069,557, filed Jul. 22, 2002, “New Substituted Indolinones, Their Manufacture and Their Use As Medicaments”.
Roth, G. J. et al, U.S. Appl. No. 09/678,682, filed Oct. 3, 2000, “Substituted Indolines Which Inhibit Receptor Tyrosine Kinases”.

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