Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...
Reexamination Certificate
2008-07-29
2008-07-29
Wilson, James O. (Department: 1624)
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitrogen attached directly or indirectly to the purine ring...
C548S465000, C548S466000, C548S467000, C548S483000
Reexamination Certificate
active
10933098
ABSTRACT:
The present invention relates to a series of substituted indole derivatives of the formula I:wherein R, R1, R2, R3, R4, X and Y are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are inhibitors of poly(adenosine 5′-diphosphate ribose) polymerase (PARP) and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases, including diseases associated with the central nervous system and cardiovascular disorders.
REFERENCES:
patent: 4148895 (1979-04-01), Lattrell et al.
patent: 6303629 (2001-10-01), Kun
patent: 7169925 (2007-01-01), Merriman et al.
patent: 2707268 (1978-08-01), None
patent: WO 99/11628 (1999-03-01), None
patent: WO 01/85687 (2001-11-01), None
Aldo Andreani et al., Nonsteroidal Antiinflammatory Agents. 2. Synthesis and Biological Activity of 2-Chloroindolecarboxylic Acids, Journal of Medicinal Chemistry, (1977, pp. 1344-1346, vol. 20-Issue 10).
Antonella Capperucci et al., Hexamethyldisilathiane: Its Use in the Conversion Of Aromatic And Heteroaromatic Azides to Amines, J. Org. Chem. (1995, pp. 2254-2256, vol. 60).
Dana Ferraris, et al et al., Design And Synthesis of Poly ADP-Ribose Polymerase-1 Inhibitors. 2. Biological Evaluation of Aza-5[H]-Phenanthridin-6-ones as Potent, Aqueous-Soluble Compounds For The Treatment Of Ischemic Injuries, Journal Med. Chem. (2003, pp. 3138-3151, vol. 46).
Pauline C. Ting et al., Substituted 1,3-Dihydro-2H-Pyrrolo[2,3-b] Pyridin-2-Ones As Potential Antiinflammatory Agents, J. Med. Chem. (1990, pp. 2697-2706, vol. 33).
Shigenobu Okuda et al., 7-Azaindole V. Investigations of Alternative Syntheses of the Ring System, J. Am. Chem. Soc. ( 1959, pp. 740-743, vol. 81).
Kadriye Benkil et al., Synthesis And Antimicrobial Activities Of Some Imidazole Substituted Indoles, Indian J. Chem., Sect B: Org. Chem. incl. Med. Chem. (2004, 43B (1), 174-179); Chem. Abst. 2004:84341 (Chem abstract only attached—2 pages).
Mark R. Player et al., 1,3-Oxazino[4,5-b]Indole-2,4-(1H,9H)-Diones And 5,6-Dimethylpyrrolo-[2,3-d]-1,3-Oxazin-2,4-(1H,7H)-Diones As Serine Protease Inhibitors, Bioorganic & Medicinal Chemistry Letters (1994, pp. 949-954, vol. 4 No. 7).
Mark R. Player et al., Synthesis Of 1,3-Disubstituted-2-Amino-5-Hydroxyindoles By Reductive Aromatization, J. Heterocyclic Chem (1993, pp. 125-127, vol. 30).
Eastwood Paul Robert
Jiang John Z.
Koehl Jack Roger
Mehdi Shujaath
Moorcroft Neil David
Aventis Pharmaveuticals Inc.
Gupta Balaram
Sackey Ebenezer
Wilson James O.
LandOfFree
Substituted indoles as inhibitors of poly (ADP-ribose)... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Substituted indoles as inhibitors of poly (ADP-ribose)..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted indoles as inhibitors of poly (ADP-ribose)... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3907423