Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2003-11-14
2009-10-27
Seaman, D. Margaret (Department: 1625)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C549S084000
Reexamination Certificate
active
07608726
ABSTRACT:
The present invention concerns the compounds of formula (I)their N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites, wherein n is 1, 2 or 3; R1is H, CN, halo, aminoC(═O), C(═O)OH, C1-4alkyloxyC(═O), C1-4alkylC(═O), mono- or di(C1-4alkyl)aminoC(═O), arylaminoC(═O), N-(aryl)-N—(C1-4alkyl)aminoC(═O), methanimidamidyl, N-hydroxy-methanimidamidyl, mono- or di(C1-4alkyl)methanimidamidyl, Het1or Het2; R2is H, C1-10alkyl, C2-10alkenyl, C3-7cycloalkyl, wherein said C1-10alkyl, C2-10alkenyl and C3-7cycloalkyl may be optionally substituted; R3is nitro, cyano, amino, halo, hydroxy, C1-4alkyloxy, hydroxyC(═O), aminoC(═O), C1-4alkyloxyC(═O), mono- or di(C1-4alkyl)aminoC(═O), C1-4alkylC(═O), methanimidamidyl, mono- or di(C1-4alkyl)methanimidamidyl, N-hydroxy-methanimidamidyl or Het1; for use as a medicine. The invention further relates to a novel subgroup of the compounds of formula (I), and to compositions comprising compounds of formula (I).
REFERENCES:
patent: WO 02/055520 (2002-07-01), None
patent: WO 02/059123 (2002-08-01), None
Ryabova et al. Russian Chemical Bulletin, International Edition, 2001 (50), 1449-1456. p. 1449, formula 1.
Latsetti et al. STN Accession No. 2002:483896;Document No. 137:352993 Abstract of Russian chemical Bulletin (Translation of lzvestiya Akademii Nauk, Seriya Khimicheskaya) (2002) 51(3), 506-512.
International Search Report dated Apr. 30, 2004 for related International Application No. PCT/EP2003/050837.
Bettens Eva
Canard Maxime Francis Jean-Marie Ghislain
De Vroey Veronique Corine Paul
Hertogs Kurt
Jochmans Dirk Edward Désiré
Chandrakumar Nizal S
Seaman D. Margaret
Tibotec Pharmaceuticals Ltd.
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