Substituted indolealkanoic acids

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S367000, C514S415000, C544S135000, C548S159000

Reexamination Certificate

active

07105514

ABSTRACT:
Disclosed are substituted indolealkanoic acids useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds and methods of treatment employing the compounds, as well as methods for their synthesis.

REFERENCES:
patent: 3557142 (1971-01-01), Bell
patent: 4251528 (1981-02-01), Brittain et al.
patent: 4283539 (1981-08-01), Schnur
patent: 4438126 (1984-03-01), Ueda et al.
patent: 4868301 (1989-09-01), Mylari et al.
patent: 4939140 (1990-07-01), Larson et al.
patent: 5064852 (1991-11-01), Howard, Jr. et al.
patent: 5236945 (1993-08-01), Mylari et al.
patent: 5304557 (1994-04-01), Mylari
patent: 5312829 (1994-05-01), Okada et al.
patent: 5330997 (1994-07-01), Mylari et al.
patent: 5332755 (1994-07-01), Butler et al.
patent: 5641800 (1997-06-01), Bach et al.
patent: 5700819 (1997-12-01), Aotsuka et al.
patent: 5744488 (1998-04-01), Cross et al.
patent: 6214991 (2001-04-01), Jones et al.
patent: 6426344 (2002-07-01), Jones et al.
patent: 0 199 543 (1986-10-01), None
patent: 0 539 117 (1993-04-01), None
patent: WO 96/03376 (1996-02-01), None
Chemical Abstracts, vol. 125, No. 10615, 1996.
Cross et al., “Selective Thromboxane Synthetase Inhibitors. 2. 3-(1H-Imidazol-1-ylmethyl)-2-methyl-1H-indole-1-propanoic Acid and Analogues”,American Chemical Society, (1986), pp. 342-346.
Doebel et al., “Derivatives of Indole-1-acetic Acid as Antiinflammatory Agents”,Journal of Medicinal Chemistry, (1972), vol. 15, No. 10, pp. 1081-1082.
Kador et al., “Aldose Reductase Inhibitors: A Potential New Class of Agents for the Harmacological Control of Certain Diabetic Complications”,Journal of Medicinal Chemistry(American Chemical Society), (1985), vol. 28, NO. 7, pp. 841-849.
Kador et al., “Pharmacophor Requirements of the Aldose Reductase Inhibitor Site”,Molecular Pharmacology, (1983), vol. 24, pp. 521-531.
Aotsuka et al., “Benzothiazol-2-Yicarboxylic Acids with Diverse Spacers: A Novel Class of Potent, Orally Active Aldose Reductase Inhibitors”,Biorganic&Medinical Chemistry Letters, (1997), vol. 7, No. 13, pp. 1677-1682.
Humber, Ph.D., L., “The Medicinal Chemistry of Aldose Reductase Inhibitors, Chapter 5”,Aldose Reductase Inhibition(Biomedical Information Corporation), (1987), pp. 326-353.
Larson et al., “Medicinal Chemistry of Aldose Reductase Inhibitors”,Medicinal Research Reviews, (1988), vol. 8, No. 2, pp. 159-186.
Dvomik D., “Inhibitors of Aldo Reductase, Chapter 16”,Design of Enzyme Inhibitors as Drugs, (1994), vol. 2, pp. 710-738.
Matassa et al., “Evolution of a Series of Peptidoleukotriene Antagonists: Synthesis and Structure/Activity Relationships of 1,3,5-Substituted Indoles and Indazoles”,J. Med. Chem., (1990), vol. 33, pp. 1781-1790.
Mylar et al., “Novel, Potent Aldose Reductase Inhibitors: 3,4-Dihydro-4-oxo-3-[[5-(trifluoromethyl)-2-benzothiazoly]methyl]-1-phthalazine-acetic Acid (Zopolrestat) and Congeners”,J. Med. Chem., (1991), vol. 34, NO. 1, pp. 108-122.
Aotsuka et al., “Novel and Potent Aldose Reductase Inhibitors: 4-Benzyl- and 4-(Benzothiazol-2-ylmethyl)-3,4-dihydro-3-oxo-2H-1,4-benzothiazine-2-acetic Acid Derivatives”,Chem. Pharm. Bull., (1994), vol. 42, No. 6, pp. 1264-1271.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Substituted indolealkanoic acids does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Substituted indolealkanoic acids, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted indolealkanoic acids will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3597026

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.